Environment-friendly MFA-based heterojunction imprinted photocatalyst (PPy@CdS@MFA imprinted photocatalyst) was synthesized by a simple photopolymerization method and surface imprinting technique. The physical and chemical properties of the PPy@CdS@MFA imprinted photocatalyst had been characterized by XRD, FT-IR, XPS, SEM, UV-vis DRS, BET, VSM, etc. In addition, the degradation rate of tetracycline (77.59%) by the PPy@CdS@MFA imprinted photocatalyst was more than twice that of ciprofloxacin (34.57%) by the PPy@CdS@MFA imprinted photocatalyst, and the coefficient of selectivity (k(selectivity)) of the PPy@CdS@MFA imprinted photocatalyst relative to CdS, CdS@MFA and non-imprinted photocatalyst were 0.71, 1.79 and 1.69, respectively. With an improved recyclability and selectivity, our work provided a feasibility analysis and exemplificative strategy for efficiently orientation degradation of targets with no secondary pollution.