In this study, the Ag3PO4/GO were prepared by ultrasound reaction. The Ag3PO4 exhibited an absorption edge at 527 nm and the band gap energies are 2.45 eV. The samples were applied to decompose tetracycline under visible light irradiation. The degradation rates of tetracycline by Ag3PO4/5wt% GO is 69.8% after 5 min irradiation, which is higher than others. After 5 cyclic degradation experiments, the degradation rate decreased form 77.7% to 74.9% after 30 min irradiation. It shows the stability of Ag3PO4/5wt% GO. Through the capture experiment, we know that h(+) and center dot O-2(-) determines the high activity of Ag3PO4/5wt% GO in tetracycline degradation.