The rate coefficient of the reaction of dimethoxymethane with OH radicals was determined in a slow-flow reactor with pulsed laser photolysis/laser-induced fluorescence technique. Temperatures ranged from 297 to 570 K at nominal pressures of 2, 5, and 10 bar (bath gas: helium). The very weak temperature dependence of the obtained rate coefficient can be expressed as: k(1)(T) = (2.9 +/- 0.5) x 10(-12) exp[(126 +/- 61)/T] cm(3) s(-1). A significant pressure dependence was not observed. The results are in very good agreement with literature data for temperatures up to 370 K whereas differences occur at T > 400 K.