Biorefineries can be a good alternative to cover the current needs of energy, such as transportation fuels and also fine chemicals. 5-hydroxymethylfurfural (HMF) can be obtained directly from biomass, and it is considered one of the most promising intermediate for the synthesis of biofuels. In this work the production of 2,5-dimethylfuran (DMF) and 2,5-dimethyltetrahydrofuran (DMTHF), two particularly attractive compounds to be used as biofuels due to its similar characteristics to gasoline, has been studied. For this purpose, a continuous fixed bed catalytic reactor was employed using HMF as raw material. Zr-supported Cu, Ce Cu, Ru Cu and Ni Cu catalysts were tested. Moreover, the catalysts textural properties were also measured-before and after the activity tesst-in order to get a deeper understanding of the relationships among the measured DMF yields and the catalyst characteristics. Final DMF, DMTHF and butanol separation was also evaluated. (C) 2019 Elsevier Ltd. All rights reserved.