We present a model to describe carbon dioxide (CO2) capture using reactive silicate-based mineral slurries exposed to a gas flow containing CO2. The model is validated through experimentation using thermally conditioned or heat activated serpentinite (hydrous metamorphic ultramafic rock) in a laboratory-scale bubble column reactor. The kinetic model developed advocates a holistic modeling approach, offering an expanded view of the dissolution of heat-activated serpentinite under lean CO2 conditions, in which the gas liquid solid system and its influence on CO2 dissolution and the coupled dissolution behavior of the material are considered in their entirety. Modeling incorporates the characteristics of the gas to liquid phase interaction, such as CO2 composition of the gas phase and interfacial area, the composition of the aqueous phase and its temperature, and compositional and morphological features of the solid. We demonstrate that such an approach is essential when considering proton-limiting conditions that are especially relevant to mineral dissolution under dilute CO2 conditions in short reaction timeframes. The model is of particular relevance to the use of reactive silicate-based minerals for the aqueous capture of CO2 from dilute CO2 gas streams. The model as developed can be used to predict CO2 capture using heat activated serpentinite slurries for a given set of operating conditions and should be adaptable for use with other alkaline materials of defined reactivity in similar or varying reaction settings by adequately specifying reaction conditions.