The method presented in this research allows the development of detailed chemical composition of hydrocarbon mixtures (petroleum and non-petroleum based) in the range of C-6 to C-33 (69 to 475 degrees C) via comprehensive twodimensional gas chromatography (GC x GC) with a flame ionization detector (FID). This method displays the protocol of obtaining a detailed chemical analysis via the classification using only 24 standard compounds without the need for a GC x GC with time-of-flight mass spectrometry (TOF/MS). The column configuration used was a reversed phase, composed of a series of a mid-polar or a polar as the primary column and a non-polar secondary column. Results were expressed as wt% for each main hydrocarbon class divided into each carbon number. Hydrocarbon classes of interest were n-paraffins, isoparaffins, mono-, di-, and tricycloparaffins, alkylbenzenes, cycloaromatics (naphthene-containing aromatic compounds), alkylnaphthalenes, biphenyls, three fused benzene rings aromatics (phenanthrenes and anthracenes), and pyrenes. This method was validated by the use of GC-FID, ASTM D1319, D6591, and standard compound mixture.