In current modeling, turbulent heat transfer of homogeneous nanofluid due to inserting double twisted tapes has been carried out. To better describing performance of unit, generation of entropy has been examined. CuO nanomaterial has been dispersed in to H2O, to help its conductivity. The pipe was under the impact of uniform heat flux. Equations describing the flow and energy balance were solved applying finite volume method. The simulations illustrate that both augmenting pumping power and height of tape result in the reduction of thermal component and the augmentation of frictional component. (C) 2019 Elsevier Ltd. All rights reserved.