The solubility and solution thermodynamics of azacyclotridecan-2-one in different solvents are indispensable for the purification and performance improvement of crystalline products in industry. In this paper, the solid-liquid equilibrium of azacyclotridecan-2-one in 15 pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, ethyl acetate, acetone, toluene, acetonitrile, dichloromethane, 1,2-dichlorobenzene, cyclohexanone, and tetrahydrofuran) from 273.15 to 323.15 K at atmospheric pressure was measured. The mole fraction solubility increased with the increase in temperature in all solvents studied. The modified Apelblat equation, Van't Hoff equation, Buchowski-Ksiazczak lambda h equation, and nonrandom two-liquid (NRTL) activity coefficient model were used to correlate the experimental data. Consequently, some association parameters were obtained. As a result, the NRTL model provided the best fitting. The solubility data provide the basic data for the design and optimization of the azacyclotridecan-2-one crystallization process.