The method of shake-flask was used in studying the solubility of flubendazole in water, n-propanol, ethanol, isopropyl alcohol, methanol, isobutyl alcohol, n-butanol, N,N-dimethylformamide, 1,4-dioxane, 2-butanone, dimethyl sulfoxide (DMSO), and N-methyl-2-pyrrolidone. The determination was made over the temperatures from 283.15 K to 333.15 K under ambient pressure p = 101.2 kPa. The values of flubendazole solubility in mole fraction in these solvents increased with rising temperature. They were highest in DMSO and lowest in water. The gained solubility was mathematically described through the Apelblat equation. The maximum average relative deviation and root-mean-square deviation were 2.69% and 3.60 x 10(-5), respectively. In addition, using the relationship analysis of linear solvation energy of solvent effect, the degree and type of solvent-solvent and solute-solvent interactions were identified.