Conventionally the deep treatment and disinfection are fulfilled by different processes for municipal wastewater treatment, this work verified a breakthrough by one process of novel flow-through electro-Fenton (EF) with graphene-modified cathode, which is usually seemed to be ineffective. This process was firstly confirmed to be cost-effective for simultaneous sulfadiazines (SDZs) degradation and disinfection from municipal secondary effluent with a very low electrical energy consumption (EEC) of 0.21 kW h/m(3), attributed to the high H2O2 production of 4.41 mg/h/cm(2) on the novel graphite felt cathode modified by electrochemically exfoliated graphed (EEGr) with a low EEC of 3.08 kW h/(kg H2O2). Compared with the ineffective SDZs degradation by the conventional flow EF, this process was more cost-effective and overcame the harsh requirements on electrolyte concentration. It also showed good effectiveness in the degradation of different antibiotics, and the graphene-modified cathode still kept stable performance after eight consecutive runs. Account for the combined action of (OH)-O-center dot and active chlorine, the formation of hydroxylated and chlorine containing by-products was confirmed, and a possible degradation mechanism for SDZs was proposed. This flow-through EF process provided an alternative method for the disinfection and antibiotics degradation by one process for the treatment and reuse of municipal secondary effluent.