With improving industrial chemical technologies Hazard and Operability Analysis (HAZOP) becomes more difficult to perform, because the technologies become more integrated and complex. It is more difficult to explore all hazard events due to the more frequent operating point transition. Therefore the experts' work becomes more and more complicated, it takes a long time to analyze thoroughly a chemical technology with respect to process safety. Applying dynamic HAZOP can help the experts to explore all hazard situations in a technology based on dynamic process simulation, therefore a framework for exploring hazard events is suggested in this work. The proposed framework works via OPC (Open Platform Communication) connection between MATLAB and Aspen HYSYS dynamic process simulator. Based on the OPC connection data from Aspen HYSYS can be efficiently analyzed, moreover process optimization can be performed with a wide range of algorithms implemented in MATLAB. Applying the proposed framework different malfunctions can be preprogrammed and the effects of malfunctions can be analyzed automatically, hence the spending time of HAZOP can be shortened. Concentration of cumene-hydroperoxide (CHP) in vacuum distillation column is chosen as a case study to show how the framework can be applied to analyze process safety related situations. The malfunctions are generated through controller failures with significant changes in setpoints.