Journal of the American Chemical Society, Vol.117, No.42, 10546-10550, 1995
Conformation of (1-C-13,N-15)Acetyl-L-Carnitine - Rotational-Echo, Double-Resonance Nuclear-Magnetic-Resonance Spectroscopy
The conformation of [1-C-13,N-15]acetyl-L-carnitine is studied by rotational-echo, double-resonance (REDOR) NMR experiments. The REDOR results show that acetyl-L-carnitine adopts an extended molecular conformation in the solid state for both crystalline and lyophilized samples. These findings are in contrast to various X-ray-determined structures of racemic acetylcarnitine showing folded conformations.