Nanotube rings are barely reported novel structures formed by the self-assembly of soft matter, as compared with nanotube structures and ring structures. The two-step self-assembly of amphiphilic copolymer AB and solvophobic copolymer CDC was studied. We found that nanotube rings can be formed from a certain mass ratio of copolymer CDC to copolymer AB and block D of certain rigidity. More interestingly, we discovered a new strategy for drug loading and release, which is different from the usual strategies reported in the literature. The present study provides a new rationale for the self-assembly of copolymers.