In this study, nanocrystalline lithium-substituted copper ferrite (Li-CuFe2O4) nanoparticles with high surface area were synthesized by using a facile and cost-effective wet chemical co-precipitation method followed by crystallization at 900 degrees C. The powder X-ray diffraction pattern endows the crystalline behavior with minimum crystallite size of 13 nm. The scanning electron microscopy image has confirmed an irregular nanoparticles formation where as the transmission electron microscopy image has identified cubical shaped crystals of polycrystalline nature, approved from the respective selected area electron diffraction spectrum. Thin films of Li-CuFe2O4 are envisaged as humidity sensors where moderate sensitivity of 2.2 M Omega/% RH towards the entire range of humidity and fast response/recovery time of 7/36 s is obtained. Notably, as-fabricated humidity sensor of Li-CuFe2O4 has confirmed similar to 99% reproducibility, confirming its chemical stability and mechanical robustness for commercial viability.