Graphene oxide (GO) was added to zinc phthalocyanine (ZnPc) and tetra nitro substituted zinc phthalocyanine (ZnPc(NO2)(4)) solutions to evaluate the photophysical interaction of GO with phthalocyanines. Dimethylformamide (DMF) and acetonitrile (MeCN) were used as solvents. GO quenching is shown to be stronger with ZnPc(NO2)(4), presenting a Stern-Volmer (K-sv) constant approximately 10 times higher than ZnPc. The presence of GO and the increase in its concentration demonstrates a different pattern of absorbance for ZnPc (NO2)(4). Singlet oxygen generation was found to be higher in DMF than MeCN enhaces with GO present. The overall singlet quantum yield of ZnPc is higher than ZnPc(NO2)(4).