H2S donors are not only useful research tools in biology, but also potential therapeutic agents. Here, we rationally designed and synthesized an ideal H2S donor using the concept of polymer-drug conjugates and stimuli-responsiveness. The results showed that the synthetic Poly(AEMATK10-co-EGMA60) was highly water soluble, noncytotoxic and can release H2S under irradiation of UV light in a controlled manner.