Extractive distillation is a common method to separate the mixture which has the low relative volatility, such as acetone and tetrahydrofuran mixture. Because the number of candidate solvents is high and the experiment is time-consuming, the selection method of solvent is important. In our previous work, quantitative structure property relationship was introduced to model and evaluate the relative volatility of acetone and tetrahydrofuran mixture. The flowsheet of extractive distillation was set up and the total annual cost was calculated with n-Octane and butyl ether as new and former solvent, respectively. Except the mathematical verification, we think that the dynamic control of the configuration of extractive distillation can also be a method to evaluate the feasibility of the built model. In this paper, we studied the dynamic control for extractive distillation with n-Octane and butyl ether as solvent and the integral of squared error was calculated for purity of two products. The results show that some indexes for n-Octane as solvent are better than that for butyl ether as solvent. The dynamic control performance is consistent with the results of economical and can be a way to judge the reliability of quantitative structure property relationship. (C) 2019 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.