The presence of psychoactive substances and/or their metabolites is confirmed, not only in urban wastewater, but also in aquatic plants and animal tissues, underlining the possible consequences for human health and ecosystems balance. As a alternative to conventional wastewater treatment methods, Advanced Oxidation Processes (AOPs) have received considerable attention for the treatment of water and wastewater contaminated with a wide variety of toxic pollutants. In this work, photocatalytic oxidation has been applied to simulated wastewater loaded with psychoactive drugs duloxetine and fiuvoxamine under artificial and solar illumination, so that process effectiveness unto urban wastewater mineralization could be evaluated. The effects on the process' efficiency of TiO2 P25 catalyst's concentration, initial concentration of H2O2 and Fe3+, pH of the solution, as well as the type of radiation, were evaluated in a bench-scale Pyrex reactor and a scaled-up solar reactor. The treatment efficiency has been followed through the evolution of the organic matter content expresses as dissolved organic carbon (DOC). Moreover, the release of inorganic ions and the decrease in phytotoxicity of the simulated wastewater has been observed after solar-induced photocatalytic treatment. (C) 2018 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.