Production of crystalline particles with high homogeneity in reaction crystallization by using pH-solubility-profile

Mitsuki Ohyama; Shoji Kudo; Shuntaro Amari; Hiroshi Takiyama

Journal of Industrial and Engineering Chemistry, Vol.75, 38-43, July, 2019

DOI10.1016/j.jiec.2019.03.003 Export Citation

Production of crystalline particles with high homogeneity in reaction crystallization by using pH-solubility-profile

Mitsuki Ohyama, Shoji Kudo, Shuntaro Amari, and Hiroshi Takiyama^†

Department of Chemical Engineering, Tokyo University of Agriculture and Technology (TUAT), Tokyo, Japan

E-mail:

The quality of crystalline particles is determined by many kinds of characteristics. Therefore, it is necessary to evaluate each characteristic comprehensively. In this study, the uniformity of each characteristic of the crystalline particles was defined and proposed as performance index “homogeneity”, and the operation method of reaction crystallization for improvement the crystal qualities was developed. Homogeneity was evaluated by using the uniformity of particle size and crystal shape. Furthermore, in order to produce the crystalline particles with high homogeneity, it was necessary to consider the effects of solution pH and the mixing methods of two solutions.

Keywords:Reaction crystallization;Agglomeration;Homogeneity of crystals

[References]

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Teschke O, Soares DM, Langmuir, 32(12), 2996 (2016)
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[1] Deb PK, Abed SN, Jaber AMY, Takade RK, Dosage Form Design Considerations, 1st ed., Academic Press, United States, pp.731 2018.

[2] Kim WS, Kim WS, Kim KS, Kim JS, Ward MD, Mater. Res. Bull., 39(2), 283 (2004)

[3] Kim JM, Chang SM, Kim KS, Chung MK, Kim WS, Colloids Surf. A: Physicochem. Eng. Asp., 375, 193 (2011)

[4] Al-Jibbouri S, Strege C, Ulrich J, J. Cryst. Growth, 236(1-3), 400 (2002)

[5] Kima JM, Changa SM, Changb JH, Kimb WS, Colloids Surf. A: Physicochem. Eng. Asp., 384, 31 (2011)

[6] Lewis AE, Seckler MM, Kramer H, Rosmalen GV, Industrial Crystallization Fundamentals and Applications, pp.130 2015.

[7] Myerson AS, Handbook of Industrial Crystallization, p.149 2002.

[8] Chen CW, Lee T, Org. Process Res. Dev., 21, 1326 (2017)

[9] Bramley AS, Hounslow MJ, Newman R, Paterson WR, Pogessi C, Chem. Eng. Res. Des., 75(2), 119 (1997)

[10] Kim WS, Kim WS, Kim KS, Kim JS, Jung TS, Ward MD, Chem. Eng. Commun., 193(3), 370 (2006)

[11] Teschke O, Soares DM, Langmuir, 32(12), 2996 (2016)

[12] Teschke O, Soares DM, J. Cryst. Growth, 475, 110 (2017)

[13] Sato H, Doki N, Yoshida S, Yokota M, Shimizu K, J. Cryst. Growth, 436, 99 (2016)

[14] Sharma SK, Verma S, Shrivastava BB, Wadhawan VK, J. Cryst. Growth, 244(3-4), 342 (2002)

[15] Miki H, Terashima T, Asakuma Y, Maeda K, Fukui K, Sep. Purif. Technol., 43(1), 71 (2005)