화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.76, 188-196, August, 2019
DOI10.1016/j.jiec.2019.03.039  Export Citation
A core-shell polymeric-inorganic hybrid nanocomposite system for MRI-visible gene delivery application in cancer immunotherapy
Jiali Cai1, Guochuang Chen2, Rongrong Jin3, 4, Changhui Deng1, Shihui Huang1, Xuexia Yuan1, Gengjia Chen1, Jing Zhao2, 5, †, Zhiyong Wang1, †, and Hua Ai3, 4
  • 1Center for Functional Biomaterials, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, PR China
  • 2Laboratory for Gene and Cell Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China
  • 3National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, PR China
  • 4Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, PR China
  • 5The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, PR China
E-mail:,
Due to the tumor immune escape mechanism, strategies like the utilization of bispecific antibodies were used to assist immunotherapy. Herein a visible polymer?inorganic hybrid gene vehicle had been prepared to deliver anti-EpCAM/anti-CD3 encoding minicircle DNA into normal cells thus these transfected cells effectively secreted bispecific antibody with bioactivity. In the experiments, this compound system exhibited excellent biocompatibility, high transfection efficiency and ultrasensitive imaging capacity. Furthermore, the transfected cells could be detected under the MR imaging system and the gene product showed an outstanding immune effect. In conclusion, this nanocomposite showed synergistic advantages in gene delivery and non-invasive MR imaging.
Keywords:Bispecific antibody;Cancer immunotherapy;Gene transfection;Magnetic resonance imaging;Superparamagnetic iron oxide
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