화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.77, 12-24, September, 2019
DOI10.1016/j.jiec.2019.04.044  Export Citation
Biodegradable polymers for modern vaccine development
Rajendran JC Bose1, 2, Minwoo Kim1, Ji Hyun Chang1, Ramasamy Paulmurugan3, James J. Moon4, Won-Gun Koh5, Soo-Hong Lee6, †, and Hansoo Park1, †
  • 1School of Integrative Engineering, Chung-Ang University, Seoul 06974, South Korea
  • 2Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Canary Center at Stanford for Cancer Early Detection, Department of Radiology, School of Medicine,, Stanford UniversitY, Stanford, CA 94305-5427, United States, Korea
  • 3Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Canary Center at Stanford for Cancer Early Detection, Department of Radiology, School of Medicine, Stanford University, Stanford, CA 94305-5427, United States, USA
  • 4Department of Pharmaceutical Sciences, Department of Biomedical Engineering & Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, United States, USA
  • 5Department of Chemical and Biomolecular Engineering, YONSEI University, 50 Yonsei-ro Seodaemun-gu, Seoul, 03722, South Korea
  • 6Department of Medical Biotechnology, Dongguk University Biomedical, Campus 32, Gyeonggi 10326, South Korea
E-mail:,
Most traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine safety and efficacy. This review summarizes the potential of biodegradable materials, including synthetic and natural polymers, for vaccine delivery. These materials are highly biocompatible and have minimal toxicity, and most biomaterial-based vaccines delivering antigens or adjuvants have been shown to improve immune response, compared to formulations consisting of the antigen alone. Therefore, these materials can be applied in modern vaccine development.
Keywords:Biodegradable polymer;Adjuvant;Vaccine delivery system;Biomaterial;Biocompatibility
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