Fractionation of turmerones from turmeric SFE isolate using semi-preparative supercritical chromatography technique

Martin Topiar; Marie Sajfrtova; Jindrich Karban; Helena Sovova

Journal of Industrial and Engineering Chemistry, Vol.77, 223-229, September, 2019

DOI10.1016/j.jiec.2019.04.041 Export Citation

Fractionation of turmerones from turmeric SFE isolate using semi-preparative supercritical chromatography technique

Martin Topiar^†, Marie Sajfrtova, Jindrich Karban, and Helena Sovova

Institute of Chemical Process Fundamentals of the CAS, v.v.i., Rozvojova 135, Prague 6, 16502, Czech Republic

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Turmeric (Curcuma longa L.) was extracted with supercritical carbon dioxide (sc-CO2) and turmerones, compounds with strong biological activity, were concentrated using semi-preparative supercritical chromatography (p-SFC) with sc-CO2. The extraction was performed at temperature of 40 °C and pressures of 9.66 MPa. Influence of pressure, type of adsorbent and feed-to-sorbent ratio on the yield and concentration of turmerones in p-SFC fractions was evaluated. Silica gel performed the best efficiency; the concentration of β-sesquiphellandrene in the first fraction increased more than 16 times, compared to the feed, and the concentration of ar-turmerone and curlone in the following fraction was almost doubled.

Keywords:Supercritical CO2;Semi-preparative SFC;Turmerones;Fractionation;Curcuma longa;Turmeric

[References]

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Sharif KM, Rahman MM, Azmir J, Shamsudin SH, Uddin MS, Fahim TK, Zaidul ISM, J. Ind. Eng. Chem., 21, 1314 (2015)
Sajfrtova M, Sovova H, Karban J, Rochova K, Pavela R, Barnet M, Ind. Crop. Prod., 47, 69 (2013)
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Reverchon E, Chem. Eng. Sci., 52(6), 1019 (1997)
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Kao L, Chen CR, Chang CMJ, J. Supercrit. Fluids, 43(2), 276 (2007)
Topiar M, Sajfrtova M, Pavela R, Machalova Z, J. Supercrit. Fluids, 97, 202 (2015)
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[Referenced By]

[1] Ndayishimiye J, Lim DJ, Chun BS, J. Ind. Eng. Chem., 57, 339 (2018)

[2] Sharif KM, Rahman MM, Azmir J, Shamsudin SH, Uddin MS, Fahim TK, Zaidul ISM, J. Ind. Eng. Chem., 21, 1314 (2015)

[3] Sajfrtova M, Sovova H, Karban J, Rochova K, Pavela R, Barnet M, Ind. Crop. Prod., 47, 69 (2013)

[4] Taylor SL, King JW, J. Chromatogr. Sci., 38, 91 (2000)

[5] Danielski L, Brunner G, Schwanke C, Zetzl C, Hense H, Donoso JPM, J. Supercrit. Fluids, 44(3), 315 (2008)

[6] BARTH D, CHOUCHI D, DELLAPORTA G, REVERCHON E, PERRUT M, J. Supercrit. Fluids, 7(3), 177 (1994)

[7] Shen Z, Mishra V, Imison B, Palmer M, Fairclough R, J. Agric. Food Chem., 50, 154 (2002)

[8] Bicchi C, Binello A, Rubiolo P, Phytochem. Anal., 10, 17 (1999)

[9] Reverchon E, Chem. Eng. Sci., 52(6), 1019 (1997)

[10] King JW, Favati F, Taylor SL, Sep. Sci. Technol., 31(13), 1843 (1996)

[11] Taylor SL, King JW, Montanari L, Fantozzi P, Blanco MA, Ital. J. Food Sci., 12, 65 (2000)

[12] Ambrogi A, Cardarelli DA, Eggers R, Lat. Am. Appl. Res., 33, 323 (2003)

[13] Schaeffer ST, Zalkow LH, Teja AS, Ind. Eng. Chem. Res., 28, 1017 (1989)

[14] Nagappan S, Lee DB, Seo DJ, Park SS, Ha CS, J. Ind. Eng. Chem., 22, 288 (2015)

[15] Singh RK, Kukrety A, Sharma OP, Baranwal S, Atray N, Ray SS, J. Ind. Eng. Chem., 37, 27 (2016)

[16] Martinez-Correa HA, Paula JT, Kayano ACAV, Queiroga CL, Magalhaes PM, Costa FTM, Cabral FA, J. Supercrit. Fluids, 119, 122 (2017)

[17] Hucklenbroich J, Fink GR, Schroeter M, Rueger MA, Hucklenbroich J, et al., Stem Cell Res. Ther., 5, 100 (2014)

[18] Tyagi AK, Prasad S, Yuan W, Li S, Aggarwal BB, Invest. New Drugs, 33, 1175 (2015)

[19] Gopalan B, Goto M, Kodama A, Hirose T, J. Agric. Food Chem., 48, 2189 (2000)

[20] Carvalho PIN, Osorio-Tobon JF, Rostagno MA, Petenate AJ, Meireles MAA, J. Supercrit. Fluids, 105, 44 (2015)

[21] Kao L, Chen CR, Chang CMJ, J. Supercrit. Fluids, 43(2), 276 (2007)

[22] Topiar M, Sajfrtova M, Pavela R, Machalova Z, J. Supercrit. Fluids, 97, 202 (2015)

[23] Adams RP, Identification of Essential Oil Components by Gas Chromatogra-phy/Mass Spectrometry, 4th ed., Allured Publishing Corporation, 2007.

[24] Wischnewski B, Wagner R, Calculation of Thermodynamic State Variables of Carbon Dioxide, 2014.