Spinel-type mixed transition metal oxides CoCuMoOx nanoparticles were synthesized through a modified sacrificial template method, by utilizing mashed carbon microspheres as templates. Compared with the direct calcination of mixture precursor, we obtained well-crystallized CoCuMnOx sample with high purity and sizes of 5-20 nm. Mixed valence states of transition metal elements are revealed by X-ray photoelectron spectroscopy, which is a desirable feature for oxygen reduction reaction (ORR) catalyst. Moreover, we further investigated the electrochemical performance of CoCuMoOx for the ORR by cyclic voltammetry, rotating disk electrode and chronoamperometry test in alkaline medium. It is revealed that CoCuMoOx exhibits both outstanding catalytic activity and super stability, which are important properties for an excellent catalyst. As a result, the CoCuMoOx holds high potential as a suitable candidate for ORR catalysts of alkaline fuel cell because of its low-cost and high-efficiency.