Homo- and copolymers of N-alkyl methacrylamides with varying alkyl pendant groups have been synthesized and investigated for their performance as kinetic hydrate inhibitors (KHIs) in slow constant cooling experiments in rocking cells using a structure II-forming synthetic gas mixture at an initial pressure of 76 bar. We have tried to polymerize disubstituted N,N-dialkyl methacrylamides; however, these were found to not homopolymerize using radical initiators. For monosubstituted N alkyl methacrylamides, the KHI performance was found to improve as the size of the alkyl pendant group increased from methyl to ethyl and then propyl (n- or iso-). The best performing homopolymer was poly(N-iso-propyl methacrylamide) (PIPMAm-I) which gave an onset temperature (average of 9 experiments) of 10.0 degrees C at 2500 ppm. The four structurally different N-butyl methacrylamides (n-, iso-, sec-, and tert-) were copolymerized with hydrophilic comonomers in order to investigate their potential as KHIs. The best performing copolymer containing butyl groups was a 1:1 copolymer of N-tert-butyl methacrylamide (tBuMAm) and N-methyl methacrylamide (MMAm) (P(tBuMAm-co-MMAm)), which gave an average onset temperature of 8.3 degrees C at 2500 ppm. The KHI performance of the N-propyl methacrylamide polymers (n- and iso-) was further investigated by adjusting the synthetic route. For example, poly(N-iso-propyl methacrylamide) (PIPMAm-IV) made and kept in n-butyl glycol ether (nBGE) as a 16.6 wt % solution gave an excellent performance, with an average onset temperature of 4.2 degrees C at a polymer concentration of 2500 ppm. The nBGE concentration was 12 500 ppm.