Journal of the American Chemical Society, Vol.118, No.28, 6634-6640, 1996
Tandem Ring-Opening Ring Closing Metathesis of Cyclic Olefins
Ruthenium alkylidene 1 has been utilized in the tandem ring opening-ring closing metathesis of cyclic olefins, This reaction produces a bicyclic molecule from a cyclic olefin. Reactivity is dependent upon strain, and thus ring size, in the substrate molecules. Competing oligomerization is observed in substrates having low ring strain; this process is inhibited by increasing dilution of the reaction or by adding alkyl substitution to the acyclic olefins.