The goal of the research would be to comprehend synergetic effect, additionally the Ni promotion level in the unsupported and Laponite supported NiMoS & NiPMoS catalysts. In this process, the sulfide catalysts were synthesized by a soft chemical approach under hydrothermal condition and also the Ni promotion was enhanced with the addition of phosphorus. The catalysts were characterized predicated on XRD, N-2-physisorption, TPR, H-2 pulse chemisorption, and XPS analysis. The catalysts were evaluated and compared for HDO of furfural (Hemicellulosic model compound) on temperature ranges from 503 K to 583 K under 20 bar H-2 pressurized reaction condition in the vapour phase reactor. The characterization of phosphorus added NiMoS catalysts exhibited improved textural properties with a suitable surface morphology, extraordinary stability, metal-support interaction, and metal dispersion on the support. The catalytic activity results revealed that the unsupported and Laponite supported NiPMoS catalyst performed better HDO conversion of furfural with remarkable high stability, producing deoxygenated hydrocarbons. Thereby, an innovative new unsupported and Laponite supported NiPMoS catalysts were successfully developed. The synergetic factor, intrinsic rate associated with the catalysts were correlated with improved textural properties, surface morphology, percentage of sulfidation of NiMo species, a large amount of acid sites, and dissociated hydrogen species of the catalysts. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.