The dissolution behavior of drugs in cosolvent mixtures is very important, especially in systems with co-solvence phenomenon. The solubility of edaravone in pure and mixed solvents was determined experimentally by using the isothermal dissolution equilibrium method within the temperature range from (273.15 to 313.15) K under atmosphere pressure (101.3 kPa). The maximum solubility was (4.72 x 10(-2) in mole fraction) obtained at 313.15 K in n-propanol, and the minimum data was found at 273.15 K in acetonitrile. However, in mixed solvents, the solubility of edaravone increased with the increasing temperature, while increased with increasing co-solvent mass fraction (w) to a maximum value at w = 0.6 and then decreased, and Extended Hildebrand Solubility Approach was applied to explain this phenomenon. In addition, the solubility data obtained were correlated with the modified Apelblat equation, lambda h equation, Jouyban-Acree model and CNIBS/R-K model. The results indicated that the modified apelblat equation and Jouyban-Acree model are more suitable to correlate solubility data of edaravone in studied pure and mixed solvents, respectively. The apparent dissolution standard enthalpy (Delta H-sol(0)), apparent molar standard Gibbs energy (Delta G(sol)(0)) and Delta S-sol(0) of edaravone in pure and mixed solvents were also evaluated. (C) 2019 Published by Elsevier Ltd.