A variety of voltammetric methods have been carried out for determination of brexpiprazole (BRX) using cyclic voltammetry (CV) and two different type anodic stripping methods; differential pulse (AS-DP) and square wave (AS-SWV) at modified carbon paste electrode with gold nanoparticles (AuNPs-CPEs). Additionally, electrochemical impedance spectroscopy (EIS) technique has been utilized for characterization of the different electrodes. Electrochemical oxidation behavior of BRX shows an irreversible anodic peak at 0.88 V versus Ag/AgCl, in Britton-Robinson buffer (BR) at pH 4.0, 50s preconcentration time and -0.5 deposition potential. Rectilinear relationship between the peak current versus concentration was obtained over the ranges of 1.32 x 10(-6)-6.45 x 10(-6) and 1.32 x 10(-7)-6.45 x 10(-7) mol L-1 for AS-DP and AS-SWV respectively. The lowest concentration that can be detected for both for AS-DP and AS-SWV was 3.99 x 10(-7) and 3.32 x 10(-8) mol L-1 respectively; the utilized methods have been devoted adequately for the estimation of BRX in its pure and dosage form. (C) 2019 The Electrochemical Society.