Complementarity of Combinatorial Chemistry and Structure-Based Ligand Design - Application to the Discovery of Novel Inhibitors of Matrix Metalloproteinases

Rockwell A; Melden M; Copeland RA; Hardman K; Decicco CP; Degrado WF

Journal of the American Chemical Society, Vol.118, No.42, 10337-10338, 1996

Rockwell A, Melden M, Copeland RA, Hardman K, Decicco CP, Degrado WF

Keywords:N-CARBOXYALKYL PEPTIDES;SELECTIVE INHIBITORS;ACID-DERIVATIVES;DRUG DISCOVERY;GELATINASE-A;POTENT;TECHNOLOGIES;STRATEGIES;RESIDUES