Packed-bed columns with fourth generation random packings offer an attractive way to implement SO2 seawater scrubbing on-board large marine ships because of small two-phase pressure drop, high capacity and high SO2 removal efficiency. SO2 seawater scrubbing was investigated via an Eulerian 3-D model based on the macroscopic volume-averaged continuity, momentum, energy and species balance equations in the liquid and gas phases. The performance of SO2 seawater absorption process in packed-bed column reactors with fourth generation random packings can be enhanced by the increase of liquid flow rate and the decrease of liquid temperature. Consequently, SO2 seawater scrubbing on-board large marine ships improves significantly in the temperate oceans with an average temperatures between 10 and 20 degrees C. The increase of pressure improves the driving force of gas-liquid mass transfer and subsequently SO2 removal process which becomes completely at lower values of liquid-to-gas ratio. SO2 seawater scrubbing at higher pressure increases the capital cost and energy requirement but offers major improvements such as total removal of SO2 at large sulfur content of fuel and prevention of losing of engine power because of the large counter pressure to the incoming exhaust. The operation with extra packed bed height allows to amplify the gas liquid contact time and consequently the absorption process performance.