Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

Juri Park; Min Jeong Lee; Guk Young Ahn; Tae Hoon Yun; Inseong Choi; Eun Seong Lee; Hyunsuk Lee; Sung-Wook Choi

Macromolecular Research, Vol.27, No.9, 839-842, September, 2019

DOI10.1007/s13233-019-7171-8 Export Citation

Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

Juri Park, Min Jeong Lee, Guk Young Ahn, Tae Hoon Yun, Inseong Choi, Eun Seong Lee, Hyunsuk Lee¹, and Sung-Wook Choi^†

Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi 14662, Korea
¹Basic Research & Innovation Division, Amorepacific R&D Center, Yongin, Gyeonggi 17074, Korea

E-mail:

This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young’s modulus, low tensile strength, low elongation to break, low hydrolytic degradation rate, and fast release profile of DEX. These results can be used to optimize properties so as to be suitable for specific applications. Our next goal is to evaluate the performance of PU microspheres as an injectable cartilage filler through in vitro and in vivo studies. In addition, the biodegradable PUs can be used for tissue-engineered scaffolds using three-dimensional printing.

Keywords:biodegradation;polyurethane;microsphere;dexamethasone

[References]

Santerre JP, Woodhouse K, Laroche G, Labow RS, Biomaterials, 26, 7457 (2005)
Huh DS, Cooper SL, Polym. Eng. Sci., 11, 369 (1971)
Grasel TG, Lee DC, Okkema AZ, Slowinski TJ, Cooper SL, Biomaterials, 9, 383 (1988)
Tatai L, Moore TG, Adhikari R, Malherbe F, Jayasekara R, Griffiths I, Gunatillake PA, Biomaterials, 28, 5407 (2007)
da Silva GR, da Silva-Cunha A, Behar-Cohen F, Ayres E, Orefice RL, Polym. Degrad. Stabil., 95, 491 (2010)
Patel A, Mequanint K, Macromol. Biosci., 7, 727 (2007)
Engelberg I, Kohn K, Biomaterials, 12, 292 (1991)
Gisselfalt K, Edberg B, Flodin P, Biomacromolecules, 3(5), 951 (2002)
Yang TF, Chin W, Cherng J, Shau M, Biomacromolecules, 5(5), 1926 (2004)
Zhang J, Doll BA, Beckman EJ, Hollinger JO, J. Biomed. Mater. Res. A, 67, 389 (2003)
Shoaib M, Bahadur A, Saeed A, Rahman MSU, Naseer MM, React. Funct. Polym., 127, 153 (2018)
Subramani S, Park YJ, Lee YS, Kim JH, Prog. Org. Coat., 48, 71 (2003)
Hsu SH, Chen CW, Hung KC, Tsai YC, Li S, Polymers, 8, 252 (2016)
Bunim JJ, Black RL, Lutwak L, Peterson RE, Whedon GD, Arthritis. Rheumatol., 1, 313 (1958)
Bian L, Stoker AM, Marberry KM, Ateshian GA, Cook JL, Hung CT, Am. J. Sport. Med., 38, 1 (2010)
Devedec FL, Boucher H, Dubins D, Allen C, Mol. Pharmaceut., 15, 1565 (2018)

[1] Santerre JP, Woodhouse K, Laroche G, Labow RS, Biomaterials, 26, 7457 (2005)

[2] Huh DS, Cooper SL, Polym. Eng. Sci., 11, 369 (1971)

[3] Grasel TG, Lee DC, Okkema AZ, Slowinski TJ, Cooper SL, Biomaterials, 9, 383 (1988)

[4] Tatai L, Moore TG, Adhikari R, Malherbe F, Jayasekara R, Griffiths I, Gunatillake PA, Biomaterials, 28, 5407 (2007)

[5] da Silva GR, da Silva-Cunha A, Behar-Cohen F, Ayres E, Orefice RL, Polym. Degrad. Stabil., 95, 491 (2010)

[6] Patel A, Mequanint K, Macromol. Biosci., 7, 727 (2007)

[7] Engelberg I, Kohn K, Biomaterials, 12, 292 (1991)

[8] Gisselfalt K, Edberg B, Flodin P, Biomacromolecules, 3(5), 951 (2002)

[9] Yang TF, Chin W, Cherng J, Shau M, Biomacromolecules, 5(5), 1926 (2004)

[10] Zhang J, Doll BA, Beckman EJ, Hollinger JO, J. Biomed. Mater. Res. A, 67, 389 (2003)

[11] Shoaib M, Bahadur A, Saeed A, Rahman MSU, Naseer MM, React. Funct. Polym., 127, 153 (2018)

[12] Subramani S, Park YJ, Lee YS, Kim JH, Prog. Org. Coat., 48, 71 (2003)

[13] Hsu SH, Chen CW, Hung KC, Tsai YC, Li S, Polymers, 8, 252 (2016)

[14] Bunim JJ, Black RL, Lutwak L, Peterson RE, Whedon GD, Arthritis. Rheumatol., 1, 313 (1958)

[15] Bian L, Stoker AM, Marberry KM, Ateshian GA, Cook JL, Hung CT, Am. J. Sport. Med., 38, 1 (2010)

[16] Devedec FL, Boucher H, Dubins D, Allen C, Mol. Pharmaceut., 15, 1565 (2018)