화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.27, No.11, 1173-1178, November, 2019
DOI10.1007/s13233-020-8044-x  Export Citation
Preparation of Degradable Polymeric Nanoparticles with Various Sizes and Surface Charges from Polycarbonate Block Copolymers
Gyu Seong Heo1, Sangho Cho2, 3, †, and Karen L. Wooley4, †
  • 1Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri 63110, United States, USA
  • 2Materials Architecturing Research Center, Korea Institute of Science and Technology, Seoul 02792, Korea
  • 3Division of Nano & Information Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea
  • 4Department of Chemistry, Department of Chemical Engineering, Department of Materials Science Engineering, and Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, United States, USA
E-mail:,
ABA-type polycarbonate block copolymers with pendant vinyl ether and benzyl functionalities were synthesized by sequential ring-opening polymerization of functional cyclic carbonate monomers using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an organobase catalyst. The vinyl ether moieties on the resulting block copolymers were readily conjugated with 3-mercaptopropionic acid, cysteamine hydrochloride, and L-cysteine hydrochloride monohydrate through thiol-ene “click” reactions, yielding anionic, cationic, and zwitterionic self-assembled nanoparticles, respectively, in corresponding buffers. The effect of pH on the size and surface charge of nanoparticles were examined.
Keywords:degradable polymeric nanoparticles;polycarbonates;click chemistry;charged micelles
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