Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles

Batakrishna Jana; Seongchan Kim; Huyeon Choi; Seongeon Jin; Kibeom Kim; Minsoo Kim; Hyojin Lee; Kwan Hyi Lee; Jungmin Lee; Myoung-Hwan Park; Youngdo Jeong; Ja-Hyoung Ryu; Chaekyu Kim

Journal of Industrial and Engineering Chemistry, Vol.81, 303-308, January, 2020

DOI10.1016/j.jiec.2019.09.018 Export Citation

Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles

Batakrishna Jana¹, Seongchan Kim², Huyeon Choi¹, Seongeon Jin¹, Kibeom Kim¹, Minsoo Kim^{2, 3}, Hyojin Lee^{2, 4}, Kwan Hyi Lee^{2, 4}, Jungmin Lee⁵, Myoung-Hwan Park⁵, Youngdo Jeong^{2, 4, †}, Ja-Hyoung Ryu^{1, †}, and Chaekyu Kim^{1, †}

¹Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, 44919, Korea
²Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Korea
³Department of Chemistry, School of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea
⁴Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Republic of Korea
⁵Department of Chemistry and Life Science, Sahmyook University, Seoul, 01795, Korea

E-mail:, ,

Despite the extended use of cationic gold nanoparticles (AuNPs) in biomedical applications, direct onepot synthesis of AuNPs with tunable size in aqueous media is limited due to the deleterious electrostatic attraction between AuCl4-anions and positively charged ligands. This paper describes the one-pot synthesis of cationic gold nanoparticles with size tunability based on host-guest chemistry. As the host molecule, cucurbit[7]uril inhibits self-aggregation in aqueous solution by threading positively charged guest ligands, which provides a shielding effect on the ligands. Reduction of the mixtures by directly adding NaBH4 generates cationic AuNPs with narrow size distributions. Furthermore, their potential in biomedical applications is demonstrated by siRNA transfection experiments. This approach relying on supramolecular-mediated interactions may provide new insights into organic/inorganic reactions that involve electrostatic disturbance.

Keywords:Supramolecular chemistry;Host-guest chemistry;Gold nanoparticle;Cucurbituril

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[2] Gotov O, Battogtokh G, Shin D, Ko YT, J. Ind. Eng. Chem., 65, 236 (2018)

[3] Gijohann DA, Seferos DS, Daniel WL, Massich MD, Patel PC, Mirkin CA, Angew. Chem.-Int. Edit., 49, 3280 (2010)

[4] Dykman L, Khlebtsov N, Chem. Soc. Rev., 41, 2256 (2012)

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[6] Dreaden EC, Alkilany AM, Huang X, Murphy CJ, El-sayed MA, Chem. Soc. Rev., 41, 2740 (2012)

[7] Riea JV, Thielemans W, Nanoscale, 9, 8525 (2017)

[8] Busseron E, Ruff Y, Moulina E, Giuseppone N, Nanoscale, 5, 7098 (2013)

[9] Hurst SJ, Lytton-Jean AKR, Mirkin CA, Anal. Chem., 78, 8313 (2006)

[10] Jeong Y, Duncan B, Park MH, Kim C, Rotello VM, Chem. Commun., 47, 12077 (2011)

[11] Yue J, Feliciano TJ, Li W, Lee A, Odom TW, Bioconjug. Chem., 28, 1791 (2017)

[12] Chen Y, Xianyu Y, Jiang X, Accounts Chem. Res., 50, 310 (2017)

[13] Whitesides GM, Nat. Biotechnol., 21, 1161 (2003)

[14] Jiang W, Kim BYS, Rutka JT, Chan WCW, Nat. Nanotechnol., 3(3), 145 (2008)

[15] Li JJ, Kawazoe N, Chen G, Biomaterials, 54, 226 (2015)

[16] Niidome T, Nakashima K, Takahashi H, Niidome Y, Chem. Commun., 1978 (2004).

[17] Ma D, Nanoscale, 6, 6415 (2014)

[18] Giljohann DA, Seferos DS, Patel PC, Millstone JE, Rosi BL, Mirkin CA, Nano Lett., 7, 3818 (2007)

[19] Lee SH, Bae KH, Kim SH, Lee KR, Park TG, Int. J. Pharm., 364, 94 (2008)

[20] Han X, Xu K, Taratulab O, Farsad K, Nanoscale, 11, 799 (2019)

[21] Ghosh P, Han G, De M, Kim C, Rotello VM, Adv. Drug. Deliv. Rev., 60, 1307 (2008)

[22] Arvizo R, Bhattacharya R, Mukherjee P, Expert Opin. Drug Deliv., 7, 753 (2010)

[23] Bhamidipati M, Fabris L, Bioconjug. Chem., 28, 449 (2017)

[24] Negishi Y, Tsukuda T, J. Am. Soc. Chem., 125, 4046 (2003)

[25] Sharma J, Mahima S, Kakade BA, Pasricha R, Mandale AB, Vijayamohanan K, J. Phys. Chem. B, 108(35), 13280 (2004)

[26] Hostetler MJ, Templeton AC, Murray RW, Langmuir, 15(11), 3782 (1999)

[27] Frens G, Nat. Phys. Sci., 241, 20 (1973)

[28] Li P, Li D, Zhang L, Li G, Wang E, Biomaterials, 29, 3617 (2008)

[29] Zhang LX, Sun XP, Song YH, Jiang X, Dong SJ, Wang EA, Langmuir, 22(6), 2838 (2006)

[30] Foley EA, Carter JD, Shan F, Guo T, Chem. Commun., 3192 (2005).

[31] Rana S, Bajaja A, Mouta R, Rotello VM, Adv. Drug Deliv. Rev., 64, 200 (2012)

[32] Sandhu KK, McIntosh CM, Simard JM, Smith SW, Rotello VM, Bioconjug. Chem., 13, 3 (2002)

[33] Lee JW, Samal S, Selvapalam N, Kim HJ, Kim K, Accounts Chem. Res., 36, 621 (2003)

[34] Tonga GY, Jeong Y, Duncan B, Mizuhara T, Mout R, Das R, Kim ST, Yeh YC, Yan B, Hou S, Rotello VM, Nat. Chem., 7, 597 (2015)

[35] Premkumar T, Geckeler KE, Chem. Asian J., 5, 2468 (2010)

[36] Kim C, Agasti SS, Zhu Z, Isaacs L, Rotello VM, Nat. Chem., 2, 962 (2010)

[37] Lee TC, Scherman OA, Chem. Eur. J., 18, 1628 (2012)

[38] Cao L, Isaacs L, Supramol. Chem., 26, 251 (2014)