The potential of a chitosan/polyurethane foam (CTS/PU) fixed-bed column for the removal of Allura Red dye (AR) from aqueous solutions was evaluated. Breakthrough curves were constructed under different conditions and optimized using response surface methodology (RSM). The empirical models Thomas, Yoon-Nelson, and Bed Depth Service Time (BDST) were fitted to the experimental data. The dynamic models of Yoon-Nelson and BDST accurately fitted the experimental data. As a result, CTS/PU can be successfully applied in a fixed-bed adsorption operation to remove AR dye.