The liquid phase catalytic exchange (LPCE) reaction is an effective process for heavy water detritiation and production of deuterium-depleted potable water. In the current study, hydrophobic carbon-supported platinum catalysts (Pt/C/PTFE) with high efficiency as reported previously for LPCE were prepared and comprehensive performance evaluation method is applied to evaluate the separation behaviors of LPCE systematically. Experimental results indicate that the optimum reaction temperature of 60-80 degrees C and the molar feed ratio G/L of 1.5-2.5 would lead to higher separation efficiencies. As to the packing method, a random packing mode with a packing ratio of hydrophobic catalysts 0.25 is recommended. In addition, thermodynamic analysis corresponds well with experimental results under lower temperature and G/L, while the suppression of kinetic factors should not be neglected when T> 80 degrees C and G/L > 1.5. (C) 2019 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.