Fifth generation district heating and cooling networks are characterized by supply temperatures in the ambient range of 15-25 degrees C, which not only reduces heat loss but also allows for integrating various kinds of low-temperature waste heat sources. The ability of these networks to absorb waste heat that is normally unrecoverable makes them an attractive solution for the future energy supply of urban areas. To enhance the adoption of these networks, this paper describes the development of a software tool to analyze the feasibility of fifth-generation of district heating and cooling systems in both new and existing districts. The research attempts to answer the question: "Which buildings should be connected to a low-temperature hydraulic network given both the incremental benefits and costs relative to the scenario of decentralized (dedicated) heating and cooling systems for each building?" Therefore, all possible network layouts of the buildings are considered where the heating and cooling demands of each building are met by the fifth-generation of district heating and cooling network. For the heating and cooling load characterization of the buildings, reduced-order models are used while renewable energy and waste heat sources are included in the network. The focus of the research lies in the development of a hydraulic model for flexible use in the urban energy modeling and the optimization of the fifth-generation of district heating and cooling network topology for a given urban district. Simulation results quantify the performance of the fifth-generation of district heating and cooling network based on various output metrics, including primary energy usage, carbon dioxide emissions, and network implementation cost.