The solubility of 3-hydroxy-2-nitropyridine in ten pure solvents and two binary mixture solvents (tetrahydrofuran + n-hexane and tetrahydrofuran + isopropanol) was measured from 278.15 to 318.15 K. The solubility order in pure solvents was tetrahydrofuran > acetone > acetonitrile > ethyl acetate > methanol > ethanol approximate to n-propanol > isopropanol > water > n-hexane. We used two models to fit the monocomponent data and three binary mixed models to fit the binary mixture solvent. For the modified Apelblat model and lambda h model, the maximum average relative deviation (ARD) values were 1.16 and 1.52%, respectively, and the maximum root-mean-square deviation (rmsd) values were 1.61, and 1.53%, respectively. For the Apelblat-Jouyban-Acree model, Jouyban-Acree model, and van't Hoff-Jouyban-Acree model, the maximum value of ARD is 3.69%, and the maximum value of rmsd is 0.48%. These models can fit the measured data well. We also discussed the effect of the interaction between solvent and solute on solubility. These experimental data are helpful for technological research and drug purification production.