By using the shake-flask method, the acetoguanamine solubilities in water, acetonitrile, methanol, n-butanol, isopropanol, isobutanol, ethanol, n-propanol, N,N-dimethylformamide (DMF), 1,4-dioxane, ethyl acetate, and ethylene glycol (EG) were acquired over the temperatures from 283.15 to 323.15 K at ambient pressure (p = 101.2 kPa). The mole fraction of acetoguanamine in equilibrated liquor increased as the temperature increased and followed the order in different solvents: DMF > EG > ethyl acetate > 1,4-dioxane > n-butanol > isobutanol > n-propanol > isopropanol > ethanol > methanol > water > acetonitrile. The acquired solubility was correlated via the Apelblat equation. The largest root-mean-square deviation value and largest relative average deviation were, respectively, 28.12 x 10(-6) and 2.38 x 10(-2).