In this work, poly(2-ethyl-2-oxazoline) (PEtOx) is crosslinked to realize a moisture- and thermo-responsive shape-memory polymer. The obtained PEtOx networks exhibit excellent shape-memory properties with storable strains of up to 650% and recovery values of 100% over at least 10 shape-memory cycles. The trigger temperature (T-trig) of 68 degrees C of a PEtOx network at a relative humidity (RH) of 0% decreases with increasing moisture and equals room temperature at an RH of 40%. Thus, programmed PEtOx networks trigger sensitively on a certain temperature/moisture combination and, further, can be programmed as well as triggered at room temperature exclusively by varying humidity. (c) 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019