In the presentwork, a novel and selective electrochemical sensor based on copper porphyrin metal organic frameworks (Cu-MOFs) and Au@Ag core-shell nanoparticles decorated multiwalled carbon nanotubes (MWCNT) was designed for the simultaneous determination of acetaminophen (ACOP) and dopamine (DA). The fabrication strategy was accomplished via drop casting of MWCNT-Au@Ag onto the bare glassy carbon electrode (GCE) and then electrodeposition of Cu-MOF on the MWCNT-Au@Ag/GCE. By combining the high surface area (400.54 m(2).g(-1)) of Cu-MOFs with superior conductivity and electrocatalytic properties of MWCNT-Au@Ag nanocomposites, the proposed sensor exhibited the remarkable performance for the electrocatalytic detection ACOP and DA. Under the optimized conditions, Cu-MOFs/MWCNT-Au@Ag/GCE delivered good differential pulse voltammetric response in the ACOP concentration of 1.0 similar to 40, 40 similar to 500 mu M and the DA concentration of 0.6 similar to 70, 70 similar to 300 mu M with the detection limit of 0.232 mu M for ACOP and 0.082 mu M for DA, separately. In addition, the designed electrochemical sensor was applied for the determination of ACOP and DA in real samples with reliable and satisfying recoveries (97.88 similar to 104.38% for ACOP and 98.28 similar to 104.40% for DA, respectively) and precisions (2.15 similar to 4.78% of RSD for ACOP and 1.47 similar to 4.46% of RSD for DA, respectively). As expected, these data suggested that the Cu-MOFs/MWCNT-Au@Ag was an excellent potential platform for simple and convenient determination of ACOP and DA. (C) 2019 The Electrochemical Society.