Surface properties are an essential feature in a wide range of functional materials. In this article, we summarize strategies developed in our group that employ nanoparticles and proteins as nanobricks to create thin-film coatings on surfaces. These coatings contain tailorable surface functionality based on the properties of the predesigned nanobricks, parlaying both the chemical and structural features of the precursor particles and proteins. This strategy is versatile, providing the rapid generation of both uniform and patterned coatings that provide "plug-and-play" customizable surfaces for materials and biomedical applications.