Concentrated suspensions of molybdenum, nickel, iron, and tungsten sulfide nanoparticles have been synthesized from inverse emulsions of aqueous solutions of molybdenum, nickel, iron, and tungsten salts in the presence of a sulfiding agent and hydrogen in a vacuum residue of oil distillation and have been tested in hydrocracking reactions of a mixture of paraffin wax and heavy cycle oil (HCO). The hydroconversion has been carried out in an autoclave at 445 degrees C and a hydrogen pressure of 7 MPa. The results of the study have shown that the catalytic activity of the synthesized catalysts in cracking reactions increases in the order: MoS2, (MoS2 + Ni7S6), Ni7S6, Fe1 - xS, (NH4)(0.25) WO3.