The features of the catalytic conversion of acetone and glycerol in a mixture with a hydrotreated vacuum distillate in the presence of zeolite catalysts containing Y and ZSM-5 have been studied. It has been shown that in the presence of zeolite Y, the highest yield of total C-2-C-4 olefins (24.1%) is achieved in the case of the conversion of the petroleum feedstock with an acetone-rich additive. The introduction of a catalytic additive based on ZSM-5 can significantly increase the yield of light olefins in the cracking of glycerol-rich feedstock. A synergistic effect in the transformation of a mixture of acetone and glycerol under these conditions has been observed, which is manifested in a decrease in the yield of C-2-C-4 olefins and an increase in the yield of gasoline fraction components. A significant influence of oxygenated feedstock additives on the intensity of hydrogen transfer reactions catalyzed by a combination of zeolites Y and ZSM-5 has been revealed.