This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts (R) type C, M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic properties and ejection force were assayed during the compression and the compacts were evaluated in compliance with the European Pharmacopoeia and subjected to other relevant testing (AFM imaging, wettability etc.). Based on the obtained results it could be stated that the C and M have very similar properties according to their similar composition. In general, it is difficult to select the best CPE as they possess different properties fitting the versatile needs of manufacturers. However, the obtained results revealed that the M and F1 are more suitable for the incorporation of moisture-sensitive ingredients than the C. (C) 2019 Elsevier B.V. All rights reserved.