화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.82, 98-104, February, 2020
DOI10.1016/j.jiec.2019.09.047  Export Citation
Selective extraction of glutaric acid from biological production systems using η-butanol
Yeong-Hoon Han, Ye-Lim Park, Soo-Yeon Yang, Hye-Rim Jung, Jeong Chan Joo1, Bong-Keun Song1, Sang Hyun Lee, Kyungmoon Park2, Jung-Oh Ahn3, and Yung-Hun Yang†
  • Department of Biological Engineering, College of Engineering, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea
  • 1Center for Bio-based Chemistry, Division of Convergence Chemistry, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, P.O. Box 107, Taejon 305-600, Republic of Korea
  • 2Department of Biological and Chemical Engineering, Hongik University, Sejong Ro 2639, Jochiwon, Sejong City, Republic of Korea
  • 3Biotechnology Process Engineering Center, Korea Research Institute Bioscience Biotechnology (KRIBB), Gwahangno, Yuseong-Gu, Daejeon 305-806, Republic of Korea
E-mail:
Glutaric acid has numerous industrial applications and it could be used as a polymer building block. Glutaric acid can be produced by chemical or biological methods. Although the biological production of glutaric acid has attracted considerable attention, there are few effective and economical processes for recovering glutaric acid from water based systems. Herein, we investigated the selective extraction of glutaric acid via physical extraction using nine different solvents compared with trioctylamine/toluene as the reactive extraction, which is the only reported method for recovering glutaric acid from biological production systems. Comparisons of the extraction yield, purity, linear solvation energy relationship between the solvents, and reactant selectivity revealed η-butanol to be a suitable solvent for the extraction of glutaric acid, with a high extraction yield and selectivity obtained in less than 30 min under optimized conditions. Furthermore, repetitive extraction allowed 98.4% of glutaric acid to be extracted from the aqueous phase with high solvent recovery and high purity, making this method suitable for practical application.
Keywords:Glutaric acid;Physical extraction;η-Butanol;Linear solvation energy relationship;Selectivity;Optimization
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