This review focuses on the acceleration of the bactericidal and fungicidal effects by uniform, adhesive Cu-based nanocomposites on textile and thin polymer surfaces. The acceleration of the bacterial inactivation kinetics mediated by Cu, TiO2/Cu and ZrO2-TiO2-Cu films in aerobic and anaerobic media is discussed for Gram negative, Gram positive bacteria and fungi. The Cu induced bacterial inactivation kinetics in the dark was observed to occur within the minute range for diverse bacteria. The characterization of the innovative Cu-films microstructure by several surface science techniques is described. This allows the correlation of the surface-reactivity features of the Cu-composite films mediating bacterial inactivation. The redox reactions on the Cu-films during the bacterial inactivation are documented by X-ray-photoelectron spectroscopy (XPS). Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy was used to monitor the changes in the functional groups leading to bacterial inactivation as a function of the bacterial inactivation time. The dependence of the inactivation kinetics on the Cu-loaded surface roughness is accounted for in qualitative way by atomic force microscopy (AFM). A mechanism for the bacterial inactivation induced by the Cu-nanoparticles by way of reactive oxygen species (ROS) in aerobic and anaerobic processes is discussed. The interfacial charge transfer (IFCT) mechanism under light irradiation between Cu and TiO2 or for the Cu with the binary oxide ZrO2-TiO2 is suggested. The relative potential band-position in the Cu-sputtered semiconductors responsible for the charge transfer is discussed. Evidence was found for the presence in anaerobic media of highly oxidative valence band holes (h+)(vb) at -0.4 eV generated by Cu2O. The variation in the interface surface potential (Eigenvalues) of the Cu-films during the bacterial inactivation was monitored and allowed to suggest the bacterial mineralization mechanism. Details for the reactions of the Cu-surfaces with Escherichia coli (E. coli) and Methicillin Resistant Staphylococcus Aureus (MRSA) inactivation are described. Evidence for the synergism between Cu and the TiO2 accelerating the bacterial inactivation kinetics is presented in this review.