A new synthesis method based on targeting is presented for the design of stagewise continuous crystallization processes. The methodology determines the optimal flow distribution to each of the crystallizers in addition to other common control variables, including temperature, concentration, and vessel volume The resulting optimization model yields a boundary-value differential equation system, which is transformed into a set of nonlinear equations through orthogonal collocation and solved numerically. For the synthesis of the continuous KNO3 crystallization process considered here, the predicted optimal network solution shows that the common tradeoff between high yield and large average crystal sizes has been successfully eradicated by the new design approach.