The equilibrium solubility of gatifloxacin in four nonaqueous solvent mixtures of N,N-dimethylformamide (DMF,1) + methanol (2), DMF (1) + ethanol (2), DMF (1) + isopropanol (2), and DMF (1) + n-propanol (2) was studied at the temperatures from 273.15 to 318.15 K under a local pressure of 101.1 kPa. The solubility values of gatifloxacin increased with an increase of the mass fraction of DMF and temperature for each system. At the same DMF composition and temperature, the mole fraction solubility of gatifloxacin was largest in the DMF (1) + n-propanol (2) mixture. The attained solubility was represented mathematically by the Jouyban-Acree, van't Hoff-Jouyban-Acree, and Apelblat-Jouyban-Acree models acquiring average relative deviations smaller than 2.49% and root-mean-square deviation smaller than 1.15 X 10(-4).