This article presents a procedure for the simultaneous optimization of the design and operation of heat exchangers under milk fouling. This scheme is based on a highly accurate dynamic model described by integral, partial differential, and algebraic equations. Design and operating parameters determined by the dynamic optimization include the length and diameter of the exchanger, the control policy, and the timing of the key operating steps. An economic objective function is used to account for the important factors related to milk hear treatment, and many operating constraints are imposed. Three heat exchanger configurations are considered to study the effect of fouling on the optimal plant design. Optimization indicates thar the cost factor due to the interruption of production is dominant, while an increase in energy consumption due to fouling is not very important. The constant wall temperature configuration proved to be the most economical. The economic impact of different control structures was also explored.