Air pollutants such as particulate matter (PM10 and PM2.5), nanoparticles, micropollutants, magnetic particles, oxides of sulfur as well as nitrogen, and ground-level ozone pose serious threats to human health and vegetation, especially crops and forests. To this end, Air Pollution Tolerance Indices (APTI) are of paramount importance as they help study effects/interactions of air pollution on plants, with possible eco-control implications for environmental management. The present study measured the APTI of certain common roadside plant species in India (at sites E and NE) to assess the impact of air pollutant and particulate matter concentrations on their biochemical/physiological parameters. The maximum concentrations of SO2, NO2, and suspended particulate matter (SPM) were found at site E during the study period of November 2011 to February 2012. APTI, ascorbic acid, and relative water content (RWC) were higher at site E compared to NE, whereas total chlorophyl content and pH were lower at site E, which was characterized by manmade roadside plantations and more industrial sites unlike the biodiversity-rich site NE. Thus, although both sites E and NE grew common plants, they showed variations in physiology as well as stress tolerance indices. Henceforth, screened potent plants from this study may be used to investigate plant-PM interactions, resulting effects/tolerance, with possible implications for environmental/air pollution amelioration, namely, assisting eco-sustainable strategies for particulate pollution control.